Acme Novelty Library has adopted numerous formats in the course of the series and, similarly, doesn't feature a continuous cast of characters. It has showcased early Ware comics, such as Quimby the Mouse from The Daily Texan, and more recent strips from New City, a Chicago weekly paper.

• Issue #20
  3/15/2017
• Issue #19
  3/15/2017
• Issue #18.5
  3/15/2017
• Issue #18
  3/15/2017
• Issue #17
  3/15/2017
• Issue #16
  3/15/2017
• Issue #15
  3/15/2017
• Issue #14
  3/15/2017
• Issue #13
  3/15/2017
• Issue #12
  3/15/2017
• Issue #11
  3/15/2017
• Issue #10
  3/15/2017
• Issue #9
  3/15/2017
• Issue #8
  3/15/2017
• Issue #7
  3/15/2017
• Issue #6
  3/15/2017
• Issue #5
  3/15/2017
• Issue #4
  3/15/2017
• Issue #3
  3/15/2017
• Issue #2
  3/15/2017
• Issue #1
  3/15/2017