A four-part series published between January and April 1996, the story begins with the New York Police Department using Brock's wife, Ann, to trap him. Brock sends the symbiote to Ann, turning her into She-Venom again and letting her escape. In issue #3, Ann is afraid of the symbiote's influence and refuses to have anything to do with Brock while he wears it. This plotline is resolved in The Amazing Spider-Man Vol.2 #19 (2000), in which Ann's experience with the symbiote triggers her suicide. The story includes contemporary Spider-Man Ben Reilly trying to bring Venom to justice.

The series also contained the four-part backup story, "Hybrid", with the Phage, Riot, Lasher and Agony symbiotes combining into a new symbiote which joins with former Vault guard Scott Washington to create the anti-hero Hybrid. The events of "Planet of the Symbiotes" take place during "Hybrid", with the defeat of the symbiotes in that story creating the Hybrid.

• Issue #4
  5/17/2016
• Issue #3
  5/17/2016
• Issue #2
  5/17/2016
• Issue #1
  5/17/2016